Exploring the impact of durvalumab on biliary tract cancer: insights from real-world clinical data
This study confirms the phase 3 trial results of durvalumab with platinum and gemcitabine, providing a substantial real-world dataset with detailed molecular characterization. No specific patient subgroup showed a markedly better response to durvalumab based on conventional NGS panels. Further research is needed to explore the link between immunotherapy responses and molecular subgroups.
Authors
- Magdalena Benda (ORCID: https://orcid.org/0000-0003-3226-1902)
- Stefan Kasper (ORCID: https://orcid.org/0000-0002-5947-8733)
- Bernhard Doleschal (ORCID: https://orcid.org/0009-0004-4813-4435)
- Hossein Taghizadeh (ORCID: https://orcid.org/0000-0002-0927-6498)
- Gerald Webersinke (ORCID: https://orcid.org/0000-0001-5654-6190)
- Sylvia Mink (ORCID: https://orcid.org/0000-0001-7615-6544)
- Gerald W. Prager (ORCID: https://orcid.org/0000-0002-7854-7781)
- Martin Schüler (ORCID: https://orcid.org/0000-0002-2166-3394)
- Holger F. Rumpold (ORCID: https://orcid.org/0000-0002-4118-0111)
- Hideo A. Baba (ORCID: https://orcid.org/0000-0002-1750-5318)
- Patrick Kirchweger (ORCID: https://orcid.org/0000-0003-2806-4594)
- Andreas Reichinger (ORCID: https://orcid.org/0000-0002-2835-5634)
- Patrick Reimann (ORCID: https://orcid.org/0000-0001-8387-3357)
- Angela Djanani (ORCID: https://orcid.org/0000-0002-2997-5157)
- Jonathan Burghofer (ORCID: https://orcid.org/0000-0001-6720-4671)
- Georg Schreil
- Thomas Winder (ORCID: https://orcid.org/0000-0003-4651-5758)
- Ilektra-Antonia Mavroeidi
- Eva-Maria Schneider
- Darius Morariu
Institutions
- Johannes Kepler University of Linz (AT)
- Innsbruck Medical University (AT)
- German Cancer Research Center (DE)
- Universität Innsbruck (AT)
- University of Zurich (CH)
- Fachhochschule Wiener Neustadt (AT)
- Landeskrankenhaus Feldkirch (AT)
- National Center for Tumor Diseases (DE)
- Universitätsklinikum St. Pölten (AT)
- Kepler Universitätsklinikum (AT)
- Essen University Hospital (DE)
- Private University in the Principality of Liechtenstein (LI)
- AGO Austria (AT)
- University of Duisburg-Essen (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1007/s00262-024-03842-y
- Citations
- 5
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86