A random survival forest-based pathomics signature classifies immunotherapy prognosis and profiles TIME and genomics in ES-SCLC patients
During the median follow-up period of 12.12 months, 118 ES-SCLC patients receiving first-line immunotherapy were recruited. The RSF model utilizing three pathomics features and liver metastases, bone metastases, smoking status, and lactate dehydrogenase, could predict the survival of first-line chemoimmunotherapy in patients with ES-SCLC with favorable discrimination and calibration. Underlyingly, the higher RSF-Score potentially indicated more infiltration of CD8<sup>+</sup> T cells in the stroma as well as a greater probability of MCL-1 amplification and EP300 mutation. At the single-cell level, MCL-1 was associated with TNFA-NFKB signaling and apoptosis-related processes. Hopefully, this noninvasive model could act as a biomarker for immunotherapy, potentially facilitating precision medicine in the management of ES-SCLC.
Authors
- Qinpei Cheng
- Qing K. Wang (ORCID: https://orcid.org/0000-0002-5639-8519)
- Tangfeng Lv (ORCID: https://orcid.org/0000-0001-7224-8468)
- Yuxin Jiang (ORCID: https://orcid.org/0009-0004-7329-5708)
- Qiuxia Wu (ORCID: https://orcid.org/0000-0003-3043-5841)
- Xiaoxia Wang (ORCID: https://orcid.org/0000-0001-7732-4917)
- Dong Wang (ORCID: https://orcid.org/0000-0001-7877-7440)
- Yu Hong Li (ORCID: https://orcid.org/0000-0001-6935-6353)
- Yueying Chen (ORCID: https://orcid.org/0000-0003-3083-421X)
- Ping Zhan
- Wanjun Lu
- Xueying Zuo
- Yong Song
- Fang Zhang (ORCID: https://orcid.org/0000-0002-9944-7448)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Southeast University (BD)
- Zhongda Hospital Southeast University (CN)
- Hebei Yiling Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-10-03
- DOI
- https://doi.org/10.1007/s00262-024-03829-9
- Citations
- 5
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Postdoctoral Science Foundation of Jiangsu Province