PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis
CAR T-cell therapy for brain malignancies appears promising. However, additional anti-PD-1 treatment did not enhance intratumoral CAR T-cell persistence or effector function, highlighting the need for novel strategies to improve CAR T-cell therapy in solid tumors.
Authors
- Jens Blobner (ORCID: https://orcid.org/0000-0002-8539-8745)
- Joerg‐Christian Tonn
- Patrick N. Harter (ORCID: https://orcid.org/0000-0001-5530-6910)
- Louisa von Baumgarten (ORCID: https://orcid.org/0000-0002-6634-0927)
- Dominic van den Heuvel (ORCID: https://orcid.org/0000-0002-8998-0396)
- Veit R. Buchholz (ORCID: https://orcid.org/0000-0003-0441-3913)
- Philipp Karschnia (ORCID: https://orcid.org/0000-0002-1254-5310)
- Alexander Beck (ORCID: https://orcid.org/0000-0001-8641-7832)
- Hellen Ishikawa‐Ankerhold (ORCID: https://orcid.org/0000-0003-0307-7022)
- Sebastian Kobold (ORCID: https://orcid.org/0000-0002-5612-4673)
- Nico Teske (ORCID: https://orcid.org/0000-0002-7153-7994)
- Laura Dengler
- Niklas Thon (ORCID: https://orcid.org/0000-0003-0011-5281)
- Anton Mühlbauer
- Marion Subklewe
- Ferdinand Schallerer
- Katharina Müller (ORCID: https://orcid.org/0000-0001-7098-4744)
- Tao Xu (ORCID: https://orcid.org/0000-0001-9359-3164)
- Constantin Eberle
- Julika J Herold
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- LMU Klinikum (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- Comprehensive Cancer Center Erlangen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1007/s00262-024-03837-9
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.57