Mitochondrial DNA copy number and the risk of autoimmune diseases: A Mendelian randomization study with meta-analysis
This MR analysis showed mtDNA-CN is causally associated with an increased risk of autoimmune hypothyroidism and rheumatoid arthritis at the genetic level. The findings have important implications for the use of mtDNA-CN as a biomarker for risk assessment of autoimmune hypothyroidism and rheumatoid arthritis in clinical practice.
Authors
- Shuangshuang Fu (ORCID: https://orcid.org/0000-0002-0135-0569)
- Xiongquan Long
- Xiaoping Xu
- Zihao Liu (ORCID: https://orcid.org/0000-0003-4878-1275)
- Yuyang Zhang (ORCID: https://orcid.org/0000-0002-7458-5684)
- Mingzhu Liu (ORCID: https://orcid.org/0000-0002-9865-2239)
- Minghao Wu (ORCID: https://orcid.org/0000-0001-7432-1788)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Hunan Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.jtauto.2024.100251
- Citations
- 9
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 2.16
Funders
- Education Department of Hunan Province
- Health Commission of Hunan Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province