Sustained BMP-2 delivery via alginate microbeads and polydopamine-coated 3D-Printed PCL/β-TCP scaffold enhances bone regeneration in long bone segmental defects
A 3D-printed PCL/β-TCP scaffold was fabricated to mimic the cortical bone of the femur. Along with the application of PDA surface modification and sustained BMP-2 release via AM, the developed scaffold could provide suitable osteoconduction, osteoinduction, and osteogenesis in both in vitro settings and in vivo rabbit femoral segmental bone defect models. Therefore, our findings suggest a promising therapeutic option for treating challenging long bone segmental defects, with potential for future clinical application.
Authors
- Woo Keyoung Kim (ORCID: https://orcid.org/0000-0001-7992-2603)
- Byung‐Jae Kang (ORCID: https://orcid.org/0000-0002-2419-1775)
- Y. Kim
- Songwan Jin (ORCID: https://orcid.org/0000-0002-1808-7920)
- Seoyun Lee (ORCID: https://orcid.org/0000-0002-6397-9557)
- Jae‐Hun Kim (ORCID: https://orcid.org/0009-0004-6000-0317)
- J.Y. Hong
Institutions
- Seoul National University (KR)
- Korea University (KR)
- Bio-Medical Science (South Korea) (KR)
- Knowledge Based Systems (United States) (US)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.jot.2024.08.013
- Citations
- 20
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 3.69
Funders
- Ministry of Education
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea