Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in <i>BRCA1</i> and <i>BRCA2</i>
Hormonal contraceptives were associated with increased BC risk for <i>BRCA1</i> mutation carriers, especially if used for longer durations. Decisions about their use in women with <i>BRCA1</i> mutations should carefully weigh the risks and benefits for each individual.
Authors
- Philip Harraka (ORCID: https://orcid.org/0000-0002-8446-558X)
- Meagan Brennan (ORCID: https://orcid.org/0000-0002-3281-7643)
- Clare Hunt
- Jessica Koehler
- Cass Hoskins
- Sarah O’Sullivan
- Nick Pachter
- James A. Chamberlain (ORCID: https://orcid.org/0000-0002-2219-9749)
- Michelle Cao
- Liz Caldon
- Heather Symecko (ORCID: https://orcid.org/0009-0008-9257-7953)
- Lesley Andrews
- Paul A. James (ORCID: https://orcid.org/0000-0002-4361-4657)
- Christian Fridolin Singer (ORCID: https://orcid.org/0000-0003-1294-0027)
- Rodney J. Scott
- Alison Colley
- Lara Lipton (ORCID: https://orcid.org/0000-0002-4891-5870)
- Kelly Metcalfe (ORCID: https://orcid.org/0000-0003-1803-2169)
- Bridget A. Robinson (ORCID: https://orcid.org/0000-0001-9483-9146)
- Michael Leonard Friedlander (ORCID: https://orcid.org/0000-0003-3090-795X)
- Jan Lubiński (ORCID: https://orcid.org/0000-0003-2931-3003)
- Anna DeFazio (ORCID: https://orcid.org/0000-0003-0057-4744)
- John L. Hopper (ORCID: https://orcid.org/0000-0002-8567-173X)
- Ashley Crook (ORCID: https://orcid.org/0000-0001-5578-0460)
- Jocelyn Lippey (ORCID: https://orcid.org/0000-0001-9977-1646)
- James M. Flanagan (ORCID: https://orcid.org/0000-0003-4955-1383)
- Leon Botes
- Rebecca Dickson
- David Gallego‐Ortega (ORCID: https://orcid.org/0000-0002-2347-7835)
- William D. Foulkes (ORCID: https://orcid.org/0000-0001-7427-4651)
- Jason S. Lee (ORCID: https://orcid.org/0000-0003-0879-934X)
- Sophie Nightingale (ORCID: https://orcid.org/0000-0002-4439-5484)
- Andrew N. Shelling (ORCID: https://orcid.org/0000-0002-5300-1934)
- Georgina Fenton (ORCID: https://orcid.org/0000-0002-2391-955X)
- Yoland Antill (ORCID: https://orcid.org/0000-0002-6366-5523)
- Ian Campbell (ORCID: https://orcid.org/0000-0002-7773-4155)
- Sian Greening
- Joanne Dixon
- Paul A. Cohen (ORCID: https://orcid.org/0000-0002-4860-9232)
- Gargi Pathak
- Kelly‐Anne Phillips (ORCID: https://orcid.org/0000-0002-0475-1771)
- Georgia Chenevix‐Trench (ORCID: https://orcid.org/0000-0002-1878-2587)
- Roger Laughlin Milne (ORCID: https://orcid.org/0000-0001-5764-7268)
- Michael Field (ORCID: https://orcid.org/0000-0002-4003-0568)
- Peter Savas (ORCID: https://orcid.org/0000-0001-5999-428X)
- Rachael Williams (ORCID: https://orcid.org/0000-0001-9007-6292)
- Joanne Shaw (ORCID: https://orcid.org/0000-0002-9543-7066)
- Clara Gaff (ORCID: https://orcid.org/0000-0003-0160-4159)
- Melissa A. Brown (ORCID: https://orcid.org/0000-0001-7068-088X)
- Sunil R. Lakhani (ORCID: https://orcid.org/0000-0003-4067-2760)
- Liz Lobb
- Esther M. John (ORCID: https://orcid.org/0000-0003-3259-8003)
- Deborah J. Marsh (ORCID: https://orcid.org/0000-0001-5899-4931)
- Irene L. Andrulis (ORCID: https://orcid.org/0000-0002-4226-6435)
- Nadine Tung (ORCID: https://orcid.org/0000-0003-1422-3734)
- Amber M. Aeilts (ORCID: https://orcid.org/0000-0001-8907-7853)
- Juliet D. French (ORCID: https://orcid.org/0000-0002-9770-0198)
- Nicholas K. Hayward (ORCID: https://orcid.org/0000-0003-4760-1033)
- Edwina Rickard
- Jo Burke (ORCID: https://orcid.org/0000-0001-5175-9226)
- Anannya Chakrabarti (ORCID: https://orcid.org/0000-0003-4003-7644)
- Kathy Tucker (ORCID: https://orcid.org/0000-0002-7180-6576)
- Peter C.C. Fong (ORCID: https://orcid.org/0000-0003-2689-8958)
- Anita Skandarajah (ORCID: https://orcid.org/0000-0001-7702-4850)
- Michael Bogwitz (ORCID: https://orcid.org/0000-0002-3293-9157)
- Amy Pearn (ORCID: https://orcid.org/0000-0001-9566-0463)
- Jodi M. Saunus (ORCID: https://orcid.org/0000-0002-4604-4709)
- Manisha Chauhan
- Raymond H. Kim (ORCID: https://orcid.org/0000-0002-2147-8674)
- Simon Bodek (ORCID: https://orcid.org/0000-0003-2128-8894)
- Eliza Courtney (ORCID: https://orcid.org/0000-0003-1017-0372)
- Martin Delatycki
- Mary Beth Terry (ORCID: https://orcid.org/0000-0002-4106-5033)
- Susan M. Domchek (ORCID: https://orcid.org/0000-0002-5914-7272)
- Christobel Saunders (ORCID: https://orcid.org/0000-0003-2281-9829)
- Jia‐Min Pang (ORCID: https://orcid.org/0000-0002-3466-7431)
- Alexa Kidd
- Andrea Eisen (ORCID: https://orcid.org/0000-0001-8037-9556)
- Gelareh Farshid (ORCID: https://orcid.org/0000-0002-2056-0561)
- Shweta Srinivasa (ORCID: https://orcid.org/0000-0003-0585-0947)
- Allison W. Kurian (ORCID: https://orcid.org/0000-0002-6175-9470)
- Elizabeth Salisbury
- Laura Forrest (ORCID: https://orcid.org/0000-0002-1126-4971)
- Katherine L. Nathanson (ORCID: https://orcid.org/0000-0002-6740-0901)
- Mike Gattas
- Saundra S. Buys (ORCID: https://orcid.org/0000-0003-4120-5697)
- Mary Ann Young
- Ingrid Winship (ORCID: https://orcid.org/0000-0001-8535-6003)
- Mitchell Lawrence
- Milita Zaheed (ORCID: https://orcid.org/0000-0002-2495-0209)
- Renea A. Taylor (ORCID: https://orcid.org/0000-0003-2609-2380)
- David J. Amor (ORCID: https://orcid.org/0000-0001-7191-8511)
- Ellen Pieper
- Geoffrey J. Lindeman (ORCID: https://orcid.org/0000-0001-9386-2416)
- Abi Ragunathan
- Briony Patterson
- Beth Y. Karlan (ORCID: https://orcid.org/0000-0002-9451-2933)
- Rosemary L. Balleine (ORCID: https://orcid.org/0000-0003-2864-4345)
- Alison Trainer
- Stacey L. Edwards (ORCID: https://orcid.org/0000-0001-7428-4139)
- Adrienne Sexton (ORCID: https://orcid.org/0000-0001-8749-1639)
- Clare L. Scott (ORCID: https://orcid.org/0000-0002-3689-5956)
- Julie K. Bassett (ORCID: https://orcid.org/0000-0003-0799-4821)
- Marion Harris (ORCID: https://orcid.org/0000-0003-4420-1915)
- Joanne Kotsopoulos (ORCID: https://orcid.org/0000-0001-9624-4218)
- Graham J. Mann (ORCID: https://orcid.org/0000-0003-1301-405X)
- Steven A. Narod (ORCID: https://orcid.org/0000-0001-5798-0626)
- Shona O’Connell
- Melissa C. Southey (ORCID: https://orcid.org/0000-0002-6313-9005)
- Mark A. Jenkins (ORCID: https://orcid.org/0000-0002-8964-6160)
- Sarah‐Jane Dawson (ORCID: https://orcid.org/0000-0002-8276-0374)
- Margaret C. Cummings (ORCID: https://orcid.org/0000-0002-7657-0240)
- Shuai Li (ORCID: https://orcid.org/0000-0002-8696-8594)
- Jessica Taylor (ORCID: https://orcid.org/0000-0003-0241-0348)
- Heather Thorne (ORCID: https://orcid.org/0000-0003-3610-2511)
- Alice Christian
- Jane Visvader
- Judy Kirk
- Peter Simpson
- Amanda Spurdle
- Michael F. Buckley
- Jacek Gronwald
- Logan Walker
- Sue Anne McLachlan
- Mary B. Daly
- Bettina Meiser
- Phyllis Butow
- Andrew Fellows
- Peter George
- Stewart Hart
- Deepa Chauhan
- James Kollias
- Susan Ramus
- Mona Saleh (ORCID: https://orcid.org/0009-0008-4124-5756)
- Ian Bennett
- Stephen Fox
- Sherene Loi
- James Cui
- Jonathan Beesley
- Wanda Cui
Institutions
- Ontario Institute for Cancer Research (CA)
- Fox Chase Cancer Center (US)
- Mount Sinai Hospital (CA)
- Beth Israel Deaconess Medical Center (US)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of California, Los Angeles (US)
- The University of Melbourne (AU)
- University of Toronto (CA)
- Cancer Council Victoria (AU)
- Lunenfeld-Tanenbaum Research Institute (CA)
- University of Utah (US)
- Columbia University Irving Medical Center (US)
- Royal Hospital for Women (AU)
- Peter MacCallum Cancer Centre (AU)
- Huntsman Cancer Institute (US)
- Women's College Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- UNSW Sydney (AU)
- Comprehensive Cancer Center Vienna (AT)
- Monash Health (AU)
- Public Health Ontario (CA)
- International Hereditary Cancer Center (PL)
- McGill University (CA)
- The Ohio State University (US)
- Monash University (AU)
- Medical University of Vienna (AT)
- Columbia University (US)
- University of Pennsylvania (US)
- Pomeranian Medical University (PL)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1200/jco.24.00176
- Citations
- 18
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 9.91
Funders
- AstraZeneca
- GlaxoSmithKline
- Clovis Oncology
- NRG Oncology
- National Cancer Institute