A murine experimental model of the pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus
An experimental model of the thrombotic effect induced by B. lanceolatus venom was developed. This effect is more pronounced in the case of venom of juvenile specimens, despite the observation that juvenile and adult venom proteomes are similar. Adult and juvenile venoms do not induce a consumption coagulopathy characteristic of other Bothrops sp venoms. Both venoms induce a conspicuous thrombocytopenia. This experimental model reproduces the main clinical findings described in these envenomings and should be useful to understand the mechanisms of the thrombotic effect.
Authors
- Rémi Nevière (ORCID: https://orcid.org/0000-0002-7966-0110)
- Jonathan Florentin (ORCID: https://orcid.org/0000-0001-7481-4128)
- Teresa Escalante (ORCID: https://orcid.org/0000-0003-4140-1620)
- Bruno Lomonte (ORCID: https://orcid.org/0000-0003-2419-6469)
- Álvaro Segura
- Gabriel Ramírez-Vargas (ORCID: https://orcid.org/0000-0002-3649-5207)
- Ivette Argüello
- Alejandro Navarro (ORCID: https://orcid.org/0000-0001-5903-270X)
- Daniela Solano
- Alexandra Rucavado (ORCID: https://orcid.org/0000-0002-7620-1760)
- E. Camacho (ORCID: https://orcid.org/0000-0003-4286-5224)
- Dabor Résière (ORCID: https://orcid.org/0000-0002-7273-2521)
- José Marı́a Gutiérrez (ORCID: https://orcid.org/0000-0001-8385-3081)
- Julián Fernández (ORCID: https://orcid.org/0000-0001-9169-2732)
- Isabel Quirós-Gutiérrez
- Hatem Kallel (ORCID: https://orcid.org/0000-0002-5663-0349)
- Karol Vargas (ORCID: https://orcid.org/0009-0006-5939-6638)
- Carlos Abarca (ORCID: https://orcid.org/0009-0000-0153-5427)
Institutions
- University of French Guiana (GF)
- Universidad de Costa Rica (CR)
- Mycologie et Sécurité des Aliments (FR)
- Centre Hospitalier Universitaire de Martinique (MQ)
- Hospital Nacional de Niños (CR)
- Université des Antilles (GP)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1371/journal.pntd.0012335
- Citations
- 4
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- Universidad de Costa Rica
- Vicerrectoría de Investigación, Universidad de Costa Rica