Maydisens, Sesterterpenoids with Anti-MDR Activity from <i>Bipolaris maydis</i>
Fourteen previously undescribed sesterterpenoids (<b>1</b>-<b>14</b>) were isolated from <i>Bipolaris maydis</i>. Their structures with absolute configurations were elucidated by NMR, HRESIMS, DP4+ calculations, ECD calculations, single-crystal X-ray diffraction analyses, and the modified Mosher's method. Compounds <b>1</b>-<b>5</b> possess an uncommon 5/11 bicyclic ring system identified from <i>B. maydis</i> for the first time. Compounds <b>6</b>-<b>14</b> have a 5/8/5 tricyclic ring system, and these compounds both possess carbonyl groups in ring A. Compound <b>10</b> showed significant reversal of paclitaxel resistance in cancer cells.
Authors
- Lianghu Gu
- Yong Shen (ORCID: https://orcid.org/0000-0002-2743-9406)
- Yonghui Zhang (ORCID: https://orcid.org/0000-0002-7222-2142)
- Qin Li (ORCID: https://orcid.org/0000-0002-3527-7531)
- Chunmei Chen (ORCID: https://orcid.org/0000-0002-4483-7465)
- Nanjin Ding
- Hucheng Zhu (ORCID: https://orcid.org/0000-0002-6672-0014)
- Mengru Yu
- Weiguang Sun
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c00658
- Citations
- 3
- Primary Topic
- Allelopathy and phytotoxic interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.80
Funders
- National Natural Science Foundation of China
- Science and Technology Department of Hubei Province
- National Key Research and Development Program of China