Discordant definitions of small airway dysfunction between spirometry and parametric response mapping: the HRCT-based study
Spirometry-SAD shows thickened airway walls, narrowed lumen, and reduced branch count, which are closely related to airway morphology. PRM shows good sensitivity to early pulmonary dysfunction, although its assessment of SAD based on gas trapping may be affected by the density of pulmonary vessels and other lung structures. Combining patient information and HRCT features, the fitted model has good predictive performance for SAD defined by both spirometry and PRM (AUC values are 0.855 and 0.808, respectively).
Authors
- Yingli Sun (ORCID: https://orcid.org/0000-0002-1888-7661)
- Yuling Yang (ORCID: https://orcid.org/0000-0002-6118-5446)
- Zongjing Ma
- Qi Lin (ORCID: https://orcid.org/0000-0001-5154-1366)
- Ming Li (ORCID: https://orcid.org/0000-0002-9242-7735)
- Bin Chen (ORCID: https://orcid.org/0000-0001-8326-4551)
- Jinjuan Lu (ORCID: https://orcid.org/0000-0001-6641-6162)
- Pan Gao (ORCID: https://orcid.org/0009-0000-0504-190X)
Institutions
- Fudan University (CN)
- Huadong Hospital (CN)
- Pulmonary Associates (US)
- YangPu Geriatric Hospital (CN)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1186/s13244-024-01819-0
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China