Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice
Cyp2c70<sup>-/-</sup> mice with a human-like bile acid composition show features of neonatal cholestasis but the extrahepatic consequences hereof have so far hardly been addressed Elevated plasma bile acids in Cyp2c70<sup>-/-</sup> pups coincide with cardiac stress and inflammation Perinatal treatment with UDCA prevents dysregulated cardiac gene expression patterns in Cyp2c70<sup>-/-</sup> pups.
Authors
- Folkert Kuipers (ORCID: https://orcid.org/0000-0003-2518-737X)
- H. de Vries (ORCID: https://orcid.org/0000-0002-1713-1002)
- Tim van Zutphen (ORCID: https://orcid.org/0000-0003-3325-9708)
- Herman H.W. Silljé (ORCID: https://orcid.org/0000-0003-3292-6302)
- Vincent W. Bloks (ORCID: https://orcid.org/0000-0001-6493-7482)
- Tim R. Eijgenraam (ORCID: https://orcid.org/0000-0001-8843-9656)
- Jan Freark de Boer (ORCID: https://orcid.org/0000-0001-6759-3291)
- Niels L. Mulder
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Fryske Akademy (NL)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1038/s41390-024-03596-4
- Citations
- 5
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Noaber Foundation
- Rijksuniversiteit Groningen