Frequency of clinical signs in patients with Cushing's syndrome and mild autonomous cortisol secretion: overlap is common
The phenotypic landscape of CS is quite variable. The frequency of comorbidities is similar between patients with CS and MACS. A relevant number of patients with overt CS have just a few clinical signs. There is also an overlap in frequency of symptoms and clinical signs between patients with CS and MACS. According to the current guidelines, 96% of our patients with MACS fall into the category "consideration of adrenalectomy". This should be kept in mind when making treatment decisions in the latter group of patients.
Authors
- Stephanie Zopp
- Felix Beuschlein (ORCID: https://orcid.org/0000-0001-7826-3984)
- Martín Reincke (ORCID: https://orcid.org/0000-0002-9817-9875)
- Leah Braun (ORCID: https://orcid.org/0000-0002-4963-5184)
- Frederick Vogel (ORCID: https://orcid.org/0000-0001-8821-8968)
- German Rubinstein (ORCID: https://orcid.org/0000-0002-7260-0748)
- Katrin Ritzel (ORCID: https://orcid.org/0000-0003-4158-5247)
- Elisabeth Nowak (ORCID: https://orcid.org/0000-0002-7323-9085)
Institutions
- University of Zurich (CH)
- LMU Klinikum (DE)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1093/ejendo/lvae127
- Citations
- 10
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- California Department of Fish and Game
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Universität Zürich
- Eva Luise und Horst Köhler Stiftung