Comprehensive Proteomic Analysis of Dysferlinopathy Unveiling Molecular Mechanisms and Biomarkers Linked to Pathological Progression
Through the aggregation of expression data from dysferlinopathy-impacted muscles exhibiting a range of pathological alterations, we identified multiple key proteins associated with the dystrophic pathology of patients with dysferlinopathy. These findings provide novel insights into the pathogenesis of dysferlinopathy and propose promising targets for future therapeutic endeavors.
Authors
- Fuze Zheng
- Qifang He (ORCID: https://orcid.org/0000-0002-3069-7916)
- Min‐Ting Lin
- Long Chen (ORCID: https://orcid.org/0000-0002-7347-3074)
- Ning Wang (ORCID: https://orcid.org/0000-0002-9655-9735)
- Xinyi Liu (ORCID: https://orcid.org/0000-0001-5983-2766)
- Xin Lin (ORCID: https://orcid.org/0000-0001-6913-4654)
- Di Wang (ORCID: https://orcid.org/0000-0003-2059-7054)
- Zhiqiang Wang (ORCID: https://orcid.org/0000-0003-2796-6318)
- Feng Lin (ORCID: https://orcid.org/0000-0002-6211-4017)
- Minghui Zeng (ORCID: https://orcid.org/0000-0002-6055-6495)
- Yuhua Lin (ORCID: https://orcid.org/0000-0002-6453-9756)
- H Chen (ORCID: https://orcid.org/0009-0007-9016-2191)
- Ying Zheng (ORCID: https://orcid.org/0000-0002-5264-6431)
Institutions
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1111/cns.70065
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province