Adipose tissue‐derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity
High-fat-diet-induced obesity aggravate the progression of TMJ OA in mice. Obese adipose tissue participates in cartilage damage through the altered miRNA in extracellular vesicles. Inhibition of miR-3074-5p/SMAD4 pathway in chondrocyte alleviated the effect of HFD-EVs on TMJ OA.
Authors
- Jingzi Zhang (ORCID: https://orcid.org/0000-0002-7190-6243)
- Baochao Li (ORCID: https://orcid.org/0000-0003-2342-8096)
- Yiwen Zhou (ORCID: https://orcid.org/0000-0002-0210-6429)
- Yanyi Wang (ORCID: https://orcid.org/0000-0003-2378-9780)
- Yue Zhao (ORCID: https://orcid.org/0000-0002-3236-6360)
- Jialing Li (ORCID: https://orcid.org/0000-0002-2777-0035)
- Cai‐Xia Zhang (ORCID: https://orcid.org/0000-0001-9671-9412)
- Li Huang (ORCID: https://orcid.org/0000-0003-3910-3982)
- Yuqin Jin
- Bingqing Zhang
- Tong Lu
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1002/ctm2.70029
- Citations
- 10
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.70
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Fundamental Research Funds for the Central Universities