Epigenetic regulation of Epstein–Barr virus: From bench to bedside
Abstract Background Epstein–Barr virus (EBV) is a double‐stranded DNA herpesvirus and establishes life‐long infection in 95% of the world's populations. Main body EBV is critically involved in multiple diseases. Aberrant signaling pathways, immune escape, and metabolic reprogramming play essential roles in EBV‐mediated pathogenesis. However, the underlying mechanisms have not yet been fully elucidated. Here we reviewed recent advances on the epigenetic regulation of EBV pathogenesis, which may translate to potential therapeutic strategies in EBV‐associated diseases. Conclusion Growing evidence has suggested that viral infections reconstruct epigenome to modulate gene expression both in the host and the virus levels.
Authors
- Jie Xiong (ORCID: https://orcid.org/0000-0002-7547-5049)
- Weili Zhao (ORCID: https://orcid.org/0000-0002-6834-1616)
- Huaman Cai (ORCID: https://orcid.org/0000-0002-9715-3235)
- Shu Cheng
- Xiao Gao
- Hao‐Xu Yang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Clinical and Translational Discovery
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1002/ctd2.357
- Citations
- 4
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Samuel Waxman Cancer Research Foundation
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- Shanghai Jiao Tong University
- Shanghai Hospital Development Center
- Shanghai Rising-Star Program
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China