THE ANTIMICROBIAL PEPTIDE SET-M33: IN VIVO EFFICACY AND TOXICITY IN DIFFERENT ANIMAL SPECIES AND ENCAPSULATION IN INHALABLE POLYMERIC NANOPARTICLES FOR PULMONARY DELIVERY
VIVO 1) Daily administration of SET-M33 at the highest doses (15 mg/kg/day and 4mg/kg/day for rats and dogs, respectively) caused renal effects, such as tubule degeneration/regeneration, elevated blood concentrations of urea and creatinine, high glucose (only in rats), all of these identifying the kidneys as a target for toxic effects,
Authors
- Laura Cresti (ORCID: https://orcid.org/0009-0008-4883-9469)
- Alessandro Pini (ORCID: https://orcid.org/0000-0002-3832-8349)
- Clelia Cortese
- Giovanni Cappello (ORCID: https://orcid.org/0000-0002-9342-0762)
- Virginia Niccolini
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p1249
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00