Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination
Our findings emphasize the proinflammatory biosignature of afucosylation in both vaccination and infection groups. Additionally, we uncovered further regulated profiles related to galactosylation in vaccinees. These findings suggest that antibody investigation for vaccination or infection should not solely focus on neutralization but should also consider effector function-related glycosylation profiling. This comprehensive information can be valuable for fine-tuning vaccine development in the future.
Authors
- San‐Yuan Wang (ORCID: https://orcid.org/0000-0002-8804-2226)
- Chung‐Yi Cheng (ORCID: https://orcid.org/0000-0003-1816-7215)
- I‐Lin Tsai (ORCID: https://orcid.org/0000-0002-3951-5197)
- Tso-Hsiao Chen (ORCID: https://orcid.org/0000-0002-3075-1054)
- Chia-Yi Chou
- Yung‐Kun Chuang (ORCID: https://orcid.org/0000-0001-6792-1814)
- Yun-Hsuan Lin
- Makoto Kuro‐o (ORCID: https://orcid.org/0000-0003-0018-7269)
- Chih‐Hsin Lee (ORCID: https://orcid.org/0000-0003-1492-3044)
- Yun-Jung Yang
Institutions
- Jichi Medical University (JP)
- Taipei Medical University Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.jmii.2024.09.007
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taipei Medical University
- Taipei Medical University Hospital
- Wan Fang Hospital