Comparison of etonogestrel bioanalytical assay results in plasma and serum within and across laboratories
Etonogestrel concentrations were highly precise within each laboratory and were comparable between serum and plasma. Results varied between laboratories (5-28% higher to 5-9% lower compared to the Organon commercial laboratory). To minimize variability, we recommend utilizing a single laboratory that conducts routine proficiency testing for etonogestrel analysis within a study.
Authors
- Anthony T. Podany (ORCID: https://orcid.org/0000-0002-8371-0379)
- Christopher Wichman (ORCID: https://orcid.org/0000-0003-4642-1591)
- Kimberly K. Scarsi (ORCID: https://orcid.org/0000-0001-9406-693X)
- Renu Nandakumar
- Lee C. Winchester (ORCID: https://orcid.org/0000-0002-6118-024X)
- Timothy Mykris (ORCID: https://orcid.org/0000-0002-0959-6563)
- Beatrice A. Chen (ORCID: https://orcid.org/0000-0002-4437-4632)
- Thomas D. Nolin (ORCID: https://orcid.org/0000-0003-4339-1382)
- David W. Erikson (ORCID: https://orcid.org/0000-0002-3383-9297)
- Catherine A. Chappell (ORCID: https://orcid.org/0000-0003-3631-3765)
- Sean N. Avedissian (ORCID: https://orcid.org/0000-0002-0935-6455)
- Raymond E. West (ORCID: https://orcid.org/0000-0002-6362-8837)
- Mark A. Marzinke (ORCID: https://orcid.org/0000-0003-1670-8786)
- Shawnalyn W Sunagawa (ORCID: https://orcid.org/0009-0005-3068-3732)
- Molly Kernan
Institutions
- Oregon National Primate Research Center (US)
- Nebraska Medical Center (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Magee-Womens Research Institute (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Contraception
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.contraception.2024.110720
- Primary Topic
- Reproductive Health and Contraception
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Merck
- Gilead Sciences
- University of Nebraska Medical Center
- Johns Hopkins University
- University of Pittsburgh
- ViiV Healthcare
- Magee-Womens Research Institute
- Mylan
- National Institutes of Health
- Oregon National Primate Research Center