Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer
Pae can serve as an effective, low-toxicity, multi-targeted drug targeting ACSS2 and glycolysis. It activates autophagy through the ACSS2/SIRT1/ATG5/ATG2B deacetylation signalling cascade, thereby exerting anti-OC effects. Our study provides new insights into the malignant mechanisms of OC and offers a novel strategy for its treatment.
Authors
- Xinqi Wang (ORCID: https://orcid.org/0000-0002-4589-4912)
- Jingchun Liu (ORCID: https://orcid.org/0000-0003-3279-4071)
- Bingshu Li (ORCID: https://orcid.org/0000-0001-8276-0449)
- Hong Li (ORCID: https://orcid.org/0000-0001-5679-9980)
- Xiaoyi Zhang (ORCID: https://orcid.org/0000-0002-7185-0470)
- Wenyi Zhang (ORCID: https://orcid.org/0000-0003-1985-9002)
- Haoyu Wang (ORCID: https://orcid.org/0000-0001-6647-598X)
- Yang Jiang (ORCID: https://orcid.org/0009-0009-5135-0573)
- Jiaxin Peng (ORCID: https://orcid.org/0000-0003-3170-7909)
- Likun Gao (ORCID: https://orcid.org/0000-0002-9445-9458)
- Siyuan Hu (ORCID: https://orcid.org/0009-0001-4819-7813)
- Ying Wang (ORCID: https://orcid.org/0000-0002-2571-9367)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Metabolism
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.metabol.2024.156041
- Citations
- 28
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 9.64
Funders
- Natural Science Foundation of Hubei Province
- Fundamental Research Funds for Central Universities of the Central South University