Downregulating LKB1 in bone marrow mesenchymal stem cells could inhibit CD4+ T cell proliferation via the PD-1/PD-L1 signaling pathway
The decreased expression of LKB1 in BMMSCs may activate the Wnt signaling pathway, leading to increased PD-L1 expression. This inhibited CD4<sup>+</sup> T cell proliferation, which might lead to impaired anti-tumor immunity in AML patients and promote AML progression.
Authors
- Jiadi Chen (ORCID: https://orcid.org/0000-0003-2328-6665)
- Yingping Cao (ORCID: https://orcid.org/0000-0002-3526-1548)
- Yaqin Zhang (ORCID: https://orcid.org/0000-0003-3436-4569)
- Chunying Zhang (ORCID: https://orcid.org/0000-0002-1813-6294)
- Xiaoyu Li (ORCID: https://orcid.org/0000-0003-3890-8332)
- Jingyi Ren
- Bihan Huang
- Zhongxian Liao
Institutions
- Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.imbio.2024.152856
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00