Perspective – Leveraging the Versatility of DNA Origami and Electrochemistry for New Sensing Modalities

Electrochemical biosensors are uniquely positioned to offer real-time in vivo molecular sensing due to their robustness to both biofluids and contaminants found in biofluids, and their adaptability for the detection of different analytes by their use of oligonucleotides or proteins as binding moiety. DNA Origami, the folding of a long DNA scaffold by hundreds of shorter oligonucleotide “staple” strands, allows the construction of nanoscale molecular objects of essentially arbitrary form, flexibility and functionality. We describe work at the intersection of these two fields and their—hopefully—bright future together.