Quantifying CSF Dynamics disruption in idiopathic normal pressure hydrocephalus using phase lag between transmantle pressure and volumetric flow rate
The exact mechanism causing the disruption of CSF circulation in idiopathic normal pressure hydrocephalus (iNPH) remains unclear. Elucidating the pathophysiology of iNPH is crucial, as it is a treatable cause of dementia. In this study, we provided an analytical and a computational method to calculate the pulsatile transmantle pressure and the phase lag between the pressure and the volumetric CSF flow rate across the cerebral aqueduct. The phase lag was significantly higher in iNPH patients than in controls and may serve as a novel biomarker of CSF dynamics disruption in iNPH.
Authors
- Benjamin D. Elder (ORCID: https://orcid.org/0000-0002-7782-7829)
- Matthew C. Murphy
- Petrice M. Cogswell (ORCID: https://orcid.org/0000-0002-8128-4476)
- Jeffrey L. Gunter (ORCID: https://orcid.org/0000-0001-7813-9078)
- Stephanie Sincomb (ORCID: https://orcid.org/0000-0003-1782-0825)
- John Huston (ORCID: https://orcid.org/0000-0003-0584-9460)
- Jeremy K. Cutsforth‐Gregory (ORCID: https://orcid.org/0000-0002-5689-4424)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Pragalv Karki (ORCID: https://orcid.org/0000-0002-4234-6945)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Jonathan Graff-Radford
- Hugo Botha
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- University of California San Diego (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Brain Multiphysics
- Published
- 2024-10-02
- DOI
- https://doi.org/10.1016/j.brain.2024.100101
- Citations
- 3
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Institutes of Health