Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans
Taken together, we found no metabolic signature of selective hepatic IR in fasting humans. DNL may contribute to hypertriglyceridemia in individuals with HI but not those with HF. Glycogenolysis and systemic glucose clearance may have a larger contribution to fasting hyperglycemia than gluconeogenesis, especially in those with HF, and these pathways should be considered for therapeutic targeting.
Authors
- Thomas Cornfield
- K. Smith (ORCID: https://orcid.org/0009-0008-4112-5025)
- Dragana Savic (ORCID: https://orcid.org/0000-0002-2181-3196)
- Thomas Marjot (ORCID: https://orcid.org/0000-0002-6542-6323)
- Ferenc E. Mózes (ORCID: https://orcid.org/0000-0002-1361-4349)
- Leanne Hodson (ORCID: https://orcid.org/0000-0002-2648-6526)
- Shilpa R. Nagarajan (ORCID: https://orcid.org/0000-0002-6666-6871)
- Paige O’Rourke
- Charlotte Green (ORCID: https://orcid.org/0000-0003-1631-3186)
- Felix Westcott (ORCID: https://orcid.org/0000-0002-5315-7963)
- Elspeth Johnson (ORCID: https://orcid.org/0000-0003-4173-7837)
- David Dearlove (ORCID: https://orcid.org/0000-0003-3529-3555)
- Barbara A. Fielding (ORCID: https://orcid.org/0000-0001-7887-809X)
- Jeremy Tomlinson (ORCID: https://orcid.org/0000-0002-3170-8533)
- Siôn Parry (ORCID: https://orcid.org/0000-0002-9037-1619)
- Jessica Mendall
Institutions
- Aston University (GB)
- University of Surrey (GB)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- Aston Medical (France) (FR)
- Oxford Biomedical Research (US)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Resonance Research (United States) (US)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1093/ejendo/lvae123
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- University of Oxford
- Novo Nordisk
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- NIHR Oxford Biomedical Research Centre