RRFERV stabilizes TEAD1 expression to mediate nasopharyngeal cancer radiation resistance rendering tumor cells vulnerable to ferroptosis
RRFERV serves as an independent prognostic factor in NPC. During the malignant progression of NPC caused by high expression of RRFERV, ferroptosis can be induced to effectively kill cancer cells and reverse the radiotherapy resistance of NPC cells, suggesting a potential treatment approach for recurrent and refractory NPC.
Authors
- Zan Hou
- Qingqing Xu (ORCID: https://orcid.org/0000-0002-7703-5872)
- Xin Wen (ORCID: https://orcid.org/0000-0003-4864-8255)
- Cheng‐long Huang (ORCID: https://orcid.org/0009-0007-9019-0280)
- Ciming Sun
- Shuanghong Song
- Lei Chen (ORCID: https://orcid.org/0009-0003-4906-5163)
- Xuan Li (ORCID: https://orcid.org/0000-0003-1052-4222)
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0001-6648-4720)
- Zhen Xu (ORCID: https://orcid.org/0009-0001-2039-7805)
- Zaishan Lin
- Jiahao Lou
- Li Li
- Suixian Zhang
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Nanfang Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1097/js9.0000000000002099
- Citations
- 10
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.85
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province