Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer
<i>TK1</i> was a tumor-specific antigen of mRNA vaccines. The patients belonging to the S2 subtype ("cold" tumor) were suitable for mRNA vaccine therapy in THCA. Notably, ten hub genes were conducted as potential biomarkers for identifying suitable patients for mRNA vaccination. These findings provided novel insights into mRNA vaccine development against THCA.
Authors
- Qiaoqiao Xu (ORCID: https://orcid.org/0000-0001-7315-5431)
- Guixin Wang (ORCID: https://orcid.org/0000-0002-4850-9207)
- Yingxi Li (ORCID: https://orcid.org/0000-0002-3848-1992)
- Yao Tian (ORCID: https://orcid.org/0000-0001-5510-0947)
- Xiaoning Wang (ORCID: https://orcid.org/0000-0002-3762-7830)
- Li Wang (ORCID: https://orcid.org/0000-0001-5691-9946)
- Zhaoyi Liu (ORCID: https://orcid.org/0000-0001-8563-7665)
- Ke Zhao (ORCID: https://orcid.org/0000-0002-1570-6407)
- Yizeng Wang
- Wenbin Song
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3389/fonc.2024.1480028
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.64