Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling
This study highlights that the DNM1L/DRP1-FIS1 axis stabilizes MRC structures through mitophagy in HGG cells while driving their OXPHOS activity ultimately leading to robust disease progression. The inhibition of the DNM1L/DRP1-FIS1 axis hinders MRC remodeling and suppresses GBM progression. We propose that down-regulation of the DNM1L/DRP1-FIS1 axis could be a potential therapeutic strategy for treating HGG.
Authors
- Q. Guo (ORCID: https://orcid.org/0000-0002-6914-637X)
- Shi‐Zhou Deng
- Yayun Wang (ORCID: https://orcid.org/0000-0002-0397-0390)
- C Gong
- Yanling Yang (ORCID: https://orcid.org/0000-0001-8246-1756)
- Y Wang
- Guopeng Zhang (ORCID: https://orcid.org/0009-0004-9577-1904)
- Shujiao Li
- Yuze Sun
- Hui Liu (ORCID: https://orcid.org/0000-0002-4105-8570)
- Zhenhua Wang (ORCID: https://orcid.org/0000-0002-2763-2281)
- Jing-Jing Tie
- Feifei Wu (ORCID: https://orcid.org/0000-0003-1384-3624)
- Xiaodong Li
- Yousheng Wu
- Xiyu Chen
Institutions
- Yan'an University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s13046-024-03194-6
- Citations
- 18
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.21