Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8+ T cell antitumor immunity
Our findings indicate that MED1 plays a pivotal role in OSCC progression through the activation of MMP9 transcription and suppression of CD8<sup>+</sup> T cell antitumor immunity, suggesting that MED1 may serve as a novel prognostic marker and therapeutic target in OSCC.
Authors
- Ruimeng Yang (ORCID: https://orcid.org/0000-0003-2768-9429)
- Qianyu Zhu (ORCID: https://orcid.org/0000-0002-2917-0404)
- Haosun Yang (ORCID: https://orcid.org/0009-0002-6027-8496)
- Lei Sui (ORCID: https://orcid.org/0000-0003-3586-9999)
- Lizhi Hu (ORCID: https://orcid.org/0000-0002-2933-2207)
- Zhaosong Meng (ORCID: https://orcid.org/0000-0002-8977-8446)
- Yue Zhang (ORCID: https://orcid.org/0000-0003-3568-0395)
- Mengke Sun
- Zhe Li (ORCID: https://orcid.org/0000-0002-9357-6839)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-1343-5199)
Institutions
- Tianjin Stomatological Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s13046-024-03191-9
- Citations
- 8
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Tianjin Medical University
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences