Itaconate induces tolerance of Staphylococcus aureus to aminoglycoside antibiotics
According to the study,we found that the immune metabolite itaconate can induce tolerance in both methicillin-resistant and -susceptible <i>S. aureus</i> to aminoglycosides. When <i>S. aureus</i> was exposed to itaconate, its growth slowed down and transcriptomic and metabolomic alterations associated with decreased energy metabolism, including the tricarboxylate cycle, glycolysis, pyruvate metabolism, and arginine biosynthesis, were observed. These changes are associated with aminoglycoside tolerance. This study highlights the role of immune signaling metabolites in bacterial antibiotic tolerance and suggests new strategies to improve antibiotic treatment by modulating the host immune response and stimulating the metabolism of bacteria.
Authors
- Lei Xu (ORCID: https://orcid.org/0000-0002-6610-115X)
- Runping Zhao
- Yanxian Yang
- Lina Qin (ORCID: https://orcid.org/0000-0002-6625-0198)
- Xilong Guo (ORCID: https://orcid.org/0000-0001-9592-3753)
- Guo‐Bao Tian (ORCID: https://orcid.org/0000-0001-6750-5482)
- Min Dai (ORCID: https://orcid.org/0000-0002-4988-9002)
- Jieyun Chen (ORCID: https://orcid.org/0000-0002-4129-1348)
Institutions
- Sun Yat-sen University (CN)
- Chengdu Medical College (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3389/fmicb.2024.1450085
- Citations
- 7
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China
- Sun Yat-sen University
- National Key Research and Development Program of China