Unveiling signaling pathways inducing MHC class II expression in neutrophils
This study provides new insights into the signaling pathways that induce MHC class II expression in neutrophils, highlighting the potential for therapeutic targeting of JAK1/2 signaling in the treatment of gram-negative bacteremia and sepsis. Understanding these mechanisms may open up novel approaches for managing inflammatory responses during sepsis.
Authors
- Daniela Finke (ORCID: https://orcid.org/0000-0003-4453-5958)
- Christoph Schmutz
- Dirk Bumann (ORCID: https://orcid.org/0000-0003-3636-4239)
- Julien Roux (ORCID: https://orcid.org/0000-0002-4192-5099)
- Nina Khanna (ORCID: https://orcid.org/0000-0002-2642-419X)
- Fabian Franzeck (ORCID: https://orcid.org/0000-0001-7510-0231)
- Jiagui Li
- Darya Palianina (ORCID: https://orcid.org/0000-0003-1785-7548)
- Pascal Forrer
- Alexander Schmidt (ORCID: https://orcid.org/0000-0002-3149-2381)
- Matthias Kreuzaler (ORCID: https://orcid.org/0000-0002-2748-7758)
- David Burckhardt
- Claudia Stühler
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- University of Basel (CH)
- University Hospital of Basel (CH)
- University Children’s Hospital Basel (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3389/fimmu.2024.1444558
- Citations
- 6
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.44