Paving the way ahead: protocol optimization of mouse models in crush syndrome related acute kidney injury research
We successfully constructed CS-AKI mouse models with different severities under the above parameters. Applying 1.5 kg for 16 h and then decompressing for 24 h induced severe AKI. These findings provide clues for further exploration of the mechanism and treatment of traumatic AKI.
Authors
- Zizheng Li
- Xinyue Wang (ORCID: https://orcid.org/0009-0003-6267-8933)
- Ou Qiao
- Yanhua Gong (ORCID: https://orcid.org/0000-0002-2693-0498)
- Lu Han (ORCID: https://orcid.org/0000-0002-7527-4829)
- Xiaohong Duan (ORCID: https://orcid.org/0000-0002-4688-4097)
- Sania Saeed (ORCID: https://orcid.org/0000-0002-9151-5792)
- Ning Li
- Li Zhang (ORCID: https://orcid.org/0000-0002-0321-3787)
- Yingjie Hou
- Herui Hao
- Xin Chen (ORCID: https://orcid.org/0000-0002-5579-0447)
- Fengjiao Bao
Institutions
- Tianjin University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3389/fphar.2024.1438127
- Citations
- 1
- Primary Topic
- Muscle and Compartmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China