Prevention and alleviation of allergic rhinitis by oral administration of Lacticaseibacillus paracasei GOLDGUT-Lpc969
Furthermore, a comparison of the genomes of three previously reported AR-effective <i>L. paracasei</i> strains (including GOLDGUTLpc969) and one non-effective <i>L. paracasei</i> strain revealed that the gene K03671 may play a key role in alleviating AR symptoms. In conclusion, this study highlights the efficacy of <i>L. paracasei</i> GOLDGUT-Lpc969 in AR prevention by suppressing the Th2 immune response and proposes the potential involvement of the functional gene K03671 in ameliorating AR symptoms. Therefore, <i>L. paracasei</i> GOLDGUT-Lpc969 shows promise as a probiotic for preventing AR.
Authors
- Jie Pan (ORCID: https://orcid.org/0000-0002-7431-9837)
- Ting Shu (ORCID: https://orcid.org/0000-0003-3050-2485)
- Huaijie Hao (ORCID: https://orcid.org/0000-0002-1928-4205)
- Silu Zhang
- Xiaoshuang Dai (ORCID: https://orcid.org/0000-0001-6563-7756)
- Zhizhu Zhang
- Pengfei Wang (ORCID: https://orcid.org/0000-0003-2454-7652)
- Kai Liu (ORCID: https://orcid.org/0000-0003-3362-180X)
- Xiaoli Zhou
- Guoxun Xiao
- Canying Hu
- Xizi Song
Institutions
- Qingdao University (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Lifetech Scientific (China) (CN)
- Qingdao Municipal Hospital (CN)
- Shenzhen Hanke Bioengineering (China) (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.3389/fimmu.2024.1444778
- Citations
- 10
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Shenzhen Research Institute, City University of Hong Kong