Preliminary antifibrotic and vasoconstrictor effects of adrenaline in Schlemm’s canal and suprachoroidal minimally invasive glaucoma surgery in primary open-angle glaucoma
What is known Fibrosis is the main cause of surgical failure in minimally invasive glaucoma surgery (MIGS). Mitomycin-C and 5-fluorouracil are too toxic to be used inside the eye. What is new Adrenaline reduced the contractility of trabecular meshwork cells and inhibited the expression of key cell cycle genes and fibrosis genes, without significant cytotoxicity. Intracameral injection of adrenaline 0.05% did not result in any ocular or systemic adverse reactions in MIGS patients.
Authors
- Henrietta Ho (ORCID: https://orcid.org/0000-0001-9346-0740)
- Cynthia Yu‐Wai‐Man (ORCID: https://orcid.org/0000-0003-4868-5187)
- Karishma Mahtani
- Mengqi Qin
- Jinyuan Luo (ORCID: https://orcid.org/0000-0001-8466-6894)
- Julia Fajardo-Sanchez (ORCID: https://orcid.org/0000-0003-2237-4671)
- Brihitejas Patel
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1007/s00417-024-06642-3
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Natural Science Foundation of Hubei Province
- Medical Research Council