Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling
The overexpression of LOC101927668, driven by SCNAs, facilitates CRC proliferation and metastasis by recruiting hnRNPD, thus perturbing the RBM47/p53/p21 signaling pathway. These findings underscore the pivotal roles of LOC101927668 and highlight its therapeutic potential in anti-CRC interventions.
Authors
- Xiangqian Su (ORCID: https://orcid.org/0000-0002-0667-8141)
- Chenghai Zhang (ORCID: https://orcid.org/0000-0001-6960-3019)
- Zaozao Wang (ORCID: https://orcid.org/0000-0001-5599-483X)
- Chenxin Wu
- Xiaowen Qiao (ORCID: https://orcid.org/0009-0002-7346-1521)
- Kai Weng (ORCID: https://orcid.org/0000-0002-2137-4525)
- Jiabo Di (ORCID: https://orcid.org/0000-0003-3665-3911)
- Beihai Jiang
- Pu Xing (ORCID: https://orcid.org/0000-0002-5755-0631)
- Haibo Han (ORCID: https://orcid.org/0000-0003-2240-5546)
- Xinying Yang (ORCID: https://orcid.org/0009-0005-9427-5033)
- Hao Hao (ORCID: https://orcid.org/0009-0000-1566-3200)
- Yifan Hou (ORCID: https://orcid.org/0009-0002-2793-3719)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Ministry of Education (ET)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s13046-024-03193-7
- Citations
- 5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China
- Peking University