Monocyte-driven inflamm-aging reduces intestinal barrier function in females
Taken together, our results suggest that higher basal intestinal permeability in combination with age-associated inflammation, increases circulating LPS in females. Thus, targeting barrier permeability in females may slow the progression of inflamm-aging, but is unlikely to prevent it.
Authors
- Candice Quin (ORCID: https://orcid.org/0000-0001-7339-6059)
- Donald J. Davidson (ORCID: https://orcid.org/0000-0002-8669-9814)
- С. А. Ермолина (ORCID: https://orcid.org/0009-0004-3562-892X)
- Jessica A. Breznik (ORCID: https://orcid.org/0000-0002-5434-9158)
- Jinhui Ma (ORCID: https://orcid.org/0000-0002-8033-1699)
- Michael G. Surette (ORCID: https://orcid.org/0000-0003-0086-4995)
- Catherine M Andary (ORCID: https://orcid.org/0009-0000-1124-9766)
- Dawn M. E. Bowdish (ORCID: https://orcid.org/0000-0001-6823-2957)
- Allison Kennedy (ORCID: https://orcid.org/0000-0002-0247-0626)
- Erica N. DeJong (ORCID: https://orcid.org/0000-0001-8212-5736)
Institutions
- University of Aberdeen (GB)
- McMaster University Medical Centre (CA)
- MRC Centre for Regenerative Medicine (GB)
- Centre for Inflammation Research (GB)
- Impact (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s12979-024-00469-6
- Citations
- 12
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Canadian Institutes of Health Research