Deciphering angiotensin converting enzyme 2 (ACE2) inhibition dynamics: Carnosine's modulatory role in breast cancer proliferation – A clinical sciences perspective
This pioneering study delineates evident dose-dependent ACE2 inhibition by carnosine. Moreover, it unveils the modulatory impact of this ACE2 inhibitor in breast cancer cell lines. Carnosine demonstrated a significant antiproliferative effect on aggressive cell lines while sparing luminal cell lines from substantial toxic or proliferative effects.
Authors
- Iman A. Mansi
- Loai M. Saadah (ORCID: https://orcid.org/0000-0003-1274-777X)
- Saja Hamed (ORCID: https://orcid.org/0000-0001-5908-5676)
- Wamidh H. Talib (ORCID: https://orcid.org/0000-0003-1942-8982)
- Zeena Shamil Attallah
- Sarah A Melhem
Institutions
- Applied Science Private University (JO)
- Hashemite University (JO)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38685
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Applied Science Private University