Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2
Inactivated SARS-CoV-2 vaccines did not potentiate thrombosis formation in atherosclerotic mice. Inactivated SARS-CoV-2 vaccines did not enhance platelet activation, or trigger the production of PF4 and antiphospholipid antibodies in patients with CAD. In light of the observed thrombotic risks associated with adenovirus-based COVID-19 vaccines, inactivated vaccines may offer a potentially safer option for individuals with CAD.
Authors
- Xin Zhao (ORCID: https://orcid.org/0000-0002-5392-1749)
- Bing Fan
- Huibin Wu
- Hongyi Wu
- Peng Zhang
- Si Zhang (ORCID: https://orcid.org/0000-0002-5682-4995)
- Yunjie Zhang (ORCID: https://orcid.org/0009-0006-4418-611X)
- Qi Zhou (ORCID: https://orcid.org/0009-0008-4521-3620)
- Huajie Xu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38336
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00