Integrating network pharmacology and experimental verification to study the mechanism of Polygonum hydropiper total flavonoids against stress-induced gastric mucosal damage
FPH exerts a gastric mucosal protective effect by upregulating antioxidant gene expression through the PI3K/Akt and Keap1/Nrf2 pathways. This study provides an experimental basis for the potential clinical treatment of SGMD with the traditional Chinese medicine <i>P. hydropiper</i>.
Authors
- Feifei Zhu (ORCID: https://orcid.org/0000-0003-4152-0857)
- Bangpei Chen
- Yiqiang Xie (ORCID: https://orcid.org/0000-0002-3038-9008)
- Shouzhong Ren (ORCID: https://orcid.org/0000-0001-5176-1975)
- Yonghui Li (ORCID: https://orcid.org/0000-0003-4320-0806)
- Ye Zhu (ORCID: https://orcid.org/0009-0003-5611-7806)
- Xueqing Huang
- Mengyu Mei
- Yunyun Zhi
Institutions
- Hainan Provincial Hospital of Traditional Chinese Medicine (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38629
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China