EVALUATION OF ANTI-DIABETIC ACTIVITY OF “ECO ENSULIN” IN EXPERIMENTALLY INDUCED DIABETES IN RATS

Aim and Objective: This study is designed to perform preclinical studies of "Eco Ensulin" for regulatory purpose of Eco Remedies.Objective of the study is to screen the antidiabetic activity of "Eco Ensulin" in experimentally induced diabetes in rats.Materials and Methods: 48 Albino Wistar Rats of either sex for study are used.The acute toxicity study of the Eco Ensulin was performed on female Albino Wistar Rats with body weight 200-250 as per OECD.After the acclimatization period, 6 rats were chosen as the normal control group.The rest of the 30 rats are divided into five groups (n=6) and are injected injection of streptozotocin (STZ) to produce hyperglycemia.The drugs are administered orally once daily for 45 days.Blood collected for various physical and biochemical parameters.Results and discussion: The present study investigation showed that the metformin (50mg/kg) and Eco Ensulin (EE200, EE400, EE600) showed gain in the body weight as compared to DC.Also showed significant decrease in the food and water intake in metformin, EE600 and EE400, EE600 groups respectively, thus decrease in the polyphagia and polydipsia.It showed decrease in the serum insulin level in the treatment groups metformin (50mg/kg), EE400, EE600 groups as