PHARMACEUTICAL COMPOSITION FOR MANAGING DIABETES WITH BERBERINE AND GYMNEMA SYLVESTRE EXTRACTS

The Present study discloses a composition for Managing Diabetes with Berberine and Gymnema Sylvestre Extracts.The Diabetes mellitus is a challenging human disorder for medical researchers, and the patients suffering from it are from all age groups.These Plants are recognized to play a crucial role as protective agent against diabetes mellitus major parts of the plant flowers leaves have been used as conventional drugs since hundreds of years.The phytochemical analysis of the methanolic extracts of Berberine and Gymnema Sylvestre extracts in-house and marketed samples showed presence of flavonoids, steroids, alkaloids, terpenoids, phenols, saponins and tannins showed a ability to maintain -cells performance and decrease glucose levels in the blood further In-vitro study was performed by using the standard protocol against plant extract.The In-vitro antidiabetic activity was performed by the alpha-amylase inhibition method.Inhibition of the alpha amylase enzyme would delay the degradation of carbohydrates, which would in turn cause a decrease in the absorption of glucose and a reduction in postprandial blood glucose levels.Based upon the experimental evidences, it was found that composition of Berberine and Gymnema sylvestre possesses higher anti-diabetic activity.