Developing a Coccidioides posadasii and SARS-CoV-2 Co-infection Model in the K18-hACE2 Transgenic Mouse
This is the first in vivo model investigation of a coinfection of SARS-CoV-2 and Coccidioides. Because of the potential for increased severity of disease in a coinfection, we suggest populations that live in areas of high coccidioidomycosis endemicity may experience higher incidence of complicated disease progression with COVID-19.
Authors
- Kimberly R. Celona (ORCID: https://orcid.org/0000-0002-6095-2041)
- Marieke L. Ramsey (ORCID: https://orcid.org/0009-0001-4023-6611)
- Bridget M. Barker (ORCID: https://orcid.org/0000-0002-3439-4517)
- Francisca J. Grill (ORCID: https://orcid.org/0000-0003-2532-8929)
- Kelly M. Shepardson (ORCID: https://orcid.org/0000-0003-3631-2594)
- Erik W. Settles (ORCID: https://orcid.org/0000-0003-4331-3683)
- Paul Keim (ORCID: https://orcid.org/0000-0003-0089-5820)
- Ashley N. Itogawa
- Daniel R. Kollath (ORCID: https://orcid.org/0000-0002-2431-3453)
- Douglas F. Lake (ORCID: https://orcid.org/0000-0001-8118-9666)
- Matthew M. Morales (ORCID: https://orcid.org/0009-0004-3137-2429)
- Mitchell Bryant
- Jinhee Yi
- Emily T. Luberto
- Ana Fabio-Braga
Institutions
- University of California, Merced (US)
- Northern Arizona University (US)
- Arizona State University (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1038/s43856-024-00610-y
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arizona Board of Regents
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases