Genetic fingerprinting with heritable phenotypes of the resting-state brain network topology

Cognitive, behavioral, and disease traits are influenced by both genetic and environmental factors. Individual differences in these traits have been associated with graph theoretical properties of resting-state networks, indicating that variations in connectome topology may be driven by genetics. In this study, we establish the heritability of global and local graph properties of resting-state networks derived from functional MRI (fMRI) and magnetoencephalography (MEG) using a large sample of twins and non-twin siblings from the Human Connectome Project. We examine the heritability of MEG in the source space, providing a more accurate estimate of genetic influences on electrophysiological networks. Our findings show that most graph measures are more heritable for MEG compared to fMRI and the heritability for MEG is greater for amplitude compared to phase synchrony in the delta, high beta, and gamma frequency bands. This suggests that the fast neuronal dynamics in MEG offer unique insights into the genetic basis of brain network organization. Furthermore, we demonstrate that brain network features can serve as genetic fingerprints to accurately identify pairs of identical twins within a cohort. These results highlight novel opportunities to relate individual connectome signatures to genetic mechanisms underlying brain function.