Investigation of the new substitution glycine to alaninewithin the Kringle-2 domain of reteplase: a molecular dynamics study
The conformational stability of r-PA conferred by glycine replacement with alanine may decrease the propensity for proteolysis in protease - rich environments across various recombinant systems and potentially enhance its production and expression levels.
Authors
- Mokhtar Jalali Javaran (ORCID: https://orcid.org/0000-0002-4668-0764)
- Kaveh Haji-Allahverdipoor
- Mohamad Bagher Khadem-Erfan
- Habib Eslami (ORCID: https://orcid.org/0000-0002-1373-480X)
- Sajad Rashidi Monfared (ORCID: https://orcid.org/0000-0001-5380-1387)
- Koosha Rokhzadi
Institutions
- Tarbiat Modares University (IR)
- Kurdistan University of Medical Sciences (IR)
- Hormozgan University of Medical Sciences (IR)
Publication Details
- Journal
- BioTechnologia
- Published
- 2024-09-30
- DOI
- https://doi.org/10.5114/bta.2024.141801
- Citations
- 2
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Tarbiat Modares University
- Kurdistan University Of Medical Sciences