Molecular characteristics of drug-susceptible Mycobacterium tuberculosis clinical isolates based on treatment duration
The identified genetic variation and gene expression patterns may influence treatment outcomes by modulating host immune responses, increasing virulence, and potentially contributing to persister cell formation in M. tuberculosis. This study provides insights into the genetic and transcriptomic factors associated with prolonged DS-TB treatment. However, our study identified molecular characteristics using a small sample size, and further detailed studies are warranted.
Authors
- Jinsoo Min (ORCID: https://orcid.org/0000-0001-6091-518X)
- Eon-Min Ko
- Ji-A Jeong
- Seonghan Kim (ORCID: https://orcid.org/0000-0001-8916-9299)
- Hyung-Jun Kim (ORCID: https://orcid.org/0000-0002-0254-965X)
- Sungkyoung Lee (ORCID: https://orcid.org/0000-0002-9701-3160)
Institutions
- Korea Disease Control and Prevention Agency (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Korea Center for Disease Control and Prevention (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Osong Public Health and Research Perspectives
- Published
- 2024-09-30
- DOI
- https://doi.org/10.24171/j.phrp.2024.0101
- Citations
- 3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Korea Disease Control and Prevention Agency
- National Institute for Health and Care Research
- Korea National Institute of Health