Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism
The research results unequivocally demonstrated that atorvastatin can modulate VPA-induced autism by suppressing inflammation, oxidative stress, and apoptosis through TLR4/NF-κB/NOX-2 signaling pathway. Atorvastatin could be a potential treatment for ASD.
Authors
- Eman Mohamad El Nashar (ORCID: https://orcid.org/0000-0002-2883-6761)
- Zienab Abdallah
- Eman A. E. Farrag
- Mamdouh Eldesoqui (ORCID: https://orcid.org/0000-0002-6589-4514)
- Mona H. Askar
- Alshimaa Magdy
- Ali M. Eldib
- Eman A. Abdulhai
- Faten Mohammed Alasiri
- Asma Nasser Saeed Alqahtani
- Safinaz M Mahmoud
- E.A. Abdel-Razik
Institutions
- Alfaisal University (SA)
- Mansoura University (EG)
- Damanhour University (EG)
- Armed Forces Hospital (SA)
- Islamic University of Madinah (SA)
- Almaarefa University
- King Khalid University (SA)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s12993-024-00250-1
- Citations
- 4
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- King Khalid University