Results From Systematic Review and Meta-analysis of the Efficacy and Safety of Two-drug Versus Three-drug (Tenofovir/Lamivudine/Dolutegravir; TLD) Regimens for HIV Treatment

equation balancing best treatment options and system sustainability.As previously said in last CROI 2024, the future of antiretroviral therapy is probably not oral for most patients [8].The clear impact on patient-reported outcomes and quality of life cannot be forgotten and must be considered in the present and future.In conclusion, the equation integrating the best therapeutic options, affordability, and sustainability will also have to address sparing unnecessary and avoidable toxicity and patients preferences regarding long-acting options in the immediate future.Moreover, the broader impact on healthcare systems, patient adherence, and overall public health must be considered to ensure that the chosen treatment strategies are not only effective, but also sustainable and aligned with the needs of the communities they are intended to serve.