Involvement of interferon γ-producing mast cells in immune responses against melanocytes in vitiligo requires Mas-related G protein-coupled receptor X2 activation
Mast cells activated by MrgX2 serve as a local IFNγ producer that bridges between innate and adaptive immune responses against MCs in early vitiligo. Targeting MrgX2-mediated mast cell activation may represent a new strategy for treating vitiligo.
Authors
- Zhi-Kai Liao (ORCID: https://orcid.org/0000-0001-9455-6568)
- Yun-Zhu Yao
- Bingqi Dong (ORCID: https://orcid.org/0009-0006-9380-4092)
- Tiechi Lei (ORCID: https://orcid.org/0000-0003-2304-827X)
- Longfei Luo
- Shan Jiang (ORCID: https://orcid.org/0000-0003-4377-4332)
- Miao Fang (ORCID: https://orcid.org/0000-0003-2006-3781)
- Yue Le (ORCID: https://orcid.org/0000-0002-0483-8420)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1097/cm9.0000000000003173
- Citations
- 7
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 2.28