The correlation of GluR3B antibody with T lymphocyte subsets and inflammatory factors and their role in the progression of epilepsy
This study demonstrates that GluR3B antibody may influence the progression of epilepsy through altering the proportion of CD4<sup>+</sup> and CD8<sup>+</sup> lymphocyte subsets and increasing proinflammatory cytokines. The seizure suppression of immunotherapy is associated with the decrease of GluR3B antibody levels. Thus, the present study contributes to a better understanding of the immunoregulatory mechanisms of autoimmune-associated epilepsy and provides a potential target for DRE.
Authors
- Qingwei Lai
- Binbin Wang (ORCID: https://orcid.org/0000-0003-2885-6428)
- Yue Chen (ORCID: https://orcid.org/0000-0001-7262-139X)
- Nuan Wang
Institutions
- Xuzhou Medical College (CN)
- China University of Mining and Technology (CN)
- Suizhou Central Hospital (CN)
- Xuzhou No.1 People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1186/s12967-024-05699-2
- Citations
- 2
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Jiangsu Commission of Health
- Natural Science Foundation of Jiangsu Province
- Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy
- Fundamental Research Funds for the Central Universities
- Xuzhou Science and Technology Program