Methyltransferase‐Like 3–Mediated N6‐Methyladenosine RNA Methylation Regulates Hypoxia‐Induced Pulmonary Arterial Smooth Muscle Cell Pyroptosis by Targeting PTEN
These results identify a new signaling pathway, the METTL3/phosphate and tension homology deleted on chromosome 10/insulin-like growth factor 2 mRNA-binding protein 2 axis, that participates in the regulation of hypoxia-induced pyroptosis.
Authors
- Yuan Jiang (ORCID: https://orcid.org/0000-0002-9078-7964)
- Xiaodong Zheng (ORCID: https://orcid.org/0000-0002-6103-9836)
- Daling Zhu (ORCID: https://orcid.org/0000-0002-6669-2236)
- Xin Wei (ORCID: https://orcid.org/0000-0003-2294-3256)
- Yingying Hao (ORCID: https://orcid.org/0000-0001-7682-4063)
- Lixin Zhang (ORCID: https://orcid.org/0000-0003-0894-9520)
- Xijuan Zhao (ORCID: https://orcid.org/0000-0002-9253-9200)
- Junting Zhang (ORCID: https://orcid.org/0000-0001-8830-628X)
- Cui Ma (ORCID: https://orcid.org/0000-0001-5603-5964)
- Yiying Li (ORCID: https://orcid.org/0009-0007-3772-5987)
- R. Shi
- Huiyu Liu (ORCID: https://orcid.org/0000-0003-4465-8501)
Institutions
- Tongji University (CN)
- Harbin Medical University (CN)
- Daqing City People's Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1161/jaha.124.034470
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.87