Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection

Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 2 years after infection. The relationship between cognitive performance, in particular episodic memory processes observed chronically after infection, and cytokine levels in the acute phase of COVID-19 has not yet been identified in humans. To determine whether the levels of cytokines IL1β, IL-6 and TNFα secreted in the acute phase of SARS-CoV-2 infection are associated and predict verbal and visuospatial episodic memory performance in humans 6 to 9 months and 12 to 15 months post-infection. The associations and predictive value of the concentration of cytokines measured in acute phase (IL-1β, IL-6, TNFα) from plasma samples of N = 33 hospitalized COVID-19 patients (mean age 61 years, 39-78, 65% in intensive care) in relation to their verbal and visuospatial episodic memory performance measured at 6-9 months and 12-15 months post-infection were analyzed. To do this, we used Spearman correlations and generalised linear mixed models. IL-1β levels were associated with verbal episodic memory total recall scores 6-9 months post-infection. At 12-15 months post-infection IL-6 predicted verbal episodic memory score. This study demonstrated that the severity of inflammatory reaction at acute phase of SARS-CoV-2 infection predicts verbal episodic memory performance in the long-term post-infection.

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Publication Details

Journal
Scientific Reports
Published
2024-09-30
DOI
https://doi.org/10.1038/s41598-024-72421-z
Citations
9
Primary Topic
Long-Term Effects of COVID-19
Type
article
Field-Weighted Citation Impact
3.32

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article

Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection

Alexandre Cionca, Matteo Coen, Karl‐Olof Lövblad, Frédéric Assal et al.
9 citations
Scientific Reports
Long-Term Effects of COVID-19
3.32
article

Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection

Alexandre Cionca, Matteo Coen, Karl‐Olof Lövblad, Frédéric Assal, Lamyae Benzakour, Basile N. Landis, Patrice H. Lalive, Isabele Jacot de Alcântara, Philippe Voruz, Jean‐Luc Reny, Jérôme Pugin, Mayssam Nehme, Julie Péron, Gilles Allali, Olivia Braillard, Gautier Bréville, Anthony Nuber‐Champier, I Guessous, Jacques Serratrice
article en
9 citations

Abstract

Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 2 years after infection. The relationship between cognitive performance, in particular episodic memory processes observed chronically after infection, and cytokine levels in the acute phase of COVID-19 has not yet been identified in humans. To determine whether the levels of cytokines IL1β, IL-6 and TNFα secreted in the acute phase of SARS-CoV-2 infection are associated and predict verbal and visuospatial episodic memory performance in humans 6 to 9 months and 12 to 15 months post-infection. The associations and predictive value of the concentration of cytokines measured in acute phase (IL-1β, IL-6, TNFα) from plasma samples of N = 33 hospitalized COVID-19 patients (mean age 61 years, 39-78, 65% in intensive care) in relation to their verbal and visuospatial episodic memory performance measured at 6-9 months and 12-15 months post-infection were analyzed. To do this, we used Spearman correlations and generalised linear mixed models. IL-1β levels were associated with verbal episodic memory total recall scores 6-9 months post-infection. At 12-15 months post-infection IL-6 predicted verbal episodic memory score. This study demonstrated that the severity of inflammatory reaction at acute phase of SARS-CoV-2 infection predicts verbal episodic memory performance in the long-term post-infection.

Scientific ReportsVol. 14(1)
University of Geneva (CH), University Hospital of Geneva (CH), Geneva College (US), University of Pennsylvania (US), University of Lausanne (CH)
National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Good health and well-being
Openalex Percentile: Top 7%
Long-Term Effects of COVID-19
3.32
DOIOpen Access PDFOpenAlex
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