Revealing the Novel Role of Purinergic Receptor P2X4 in Phagocytic Uptake After Ischemic Stroke
This study suggests that blockade or absence of P2X4R increases phagocytic uptake of damaged tissue following ischemic stroke. Taken together with previous reports detailing how P2X4R inhibition is protective following stroke, our results demonstrate P2X4R may mediate long-term resolution after ischemic stroke by enhancing phagocytic clearance.
Authors
- Sanjeev Kumar Yadav (ORCID: https://orcid.org/0000-0002-4136-2011)
- Arun Kumar Yadawa (ORCID: https://orcid.org/0000-0002-4684-5274)
- Daylín Gamiotea Turro (ORCID: https://orcid.org/0000-0001-7600-8429)
- Chunxia Cronin
- Rajkumar Verma (ORCID: https://orcid.org/0000-0002-1123-6508)
- Bruce T. Liang (ORCID: https://orcid.org/0000-0002-4444-387X)
- Mary‐Katherine Cormier
Institutions
- UConn Health (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-09-30
- DOI
- https://doi.org/10.1161/jaha.124.037148
- Citations
- 2
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- American Heart Association