DAC and CLAM are equally effective as early second induction in newly diagnosed AML patients with persistent leukemia in early bone marrow evaluation – a retrospective analysis of Polish Adult Leukemia Group
This study presents a retrospective analysis of patients with acute myeloid leukemia < 60 years of age, who had ≥10% blasts in early bone marrow evaluation on day 14 of their first DAC (daunorubicin + AraC + cladribine) induction cycle. Patients included in this analysis were treated according to the PALG-AML-1/2012 and PALG AML-1/2016 studies. As the second early induction, 22 patients received DAC and 35 patients received CLAM (cladribine + AraC + mitoxantrone). There was no significant difference between patients treated with CLAM and those treated with DAC chemotherapy in terms of overall survival (OS after 2 years 52% vs. 76% for DAC, HR 0.68, 95% CI: 0.26–1.77, p = 0.4). Furthermore, there was no significant difference in composite complete remission (cCR) rates between the two treatment regimens: 60% (21/35) for CLAM and 54.6% (12/22) for DAC (p > 0.05). Both treatment regimens had a similar toxicity profile and early death rate.
Authors
- Martyna Włodarczyk (ORCID: https://orcid.org/0000-0002-3059-4175)
- Agnieszka Pluta (ORCID: https://orcid.org/0000-0001-8551-7452)
- Ewa Wawrzyniak (ORCID: https://orcid.org/0000-0001-6159-0129)
- Agnieszka Wierzbowska (ORCID: https://orcid.org/0000-0001-7909-457X)
- Janusz Hałka (ORCID: https://orcid.org/0000-0003-0493-6167)
- Marek Hus (ORCID: https://orcid.org/0000-0002-9036-6625)
- Marta Sobas (ORCID: https://orcid.org/0000-0003-0781-8668)
- Agata Obara
- Elżbieta Wiater
- Łukasz Bołkuń (ORCID: https://orcid.org/0000-0002-6629-8626)
- Edyta Cichocka (ORCID: https://orcid.org/0000-0002-8172-0071)
- Grzegorz Helbig (ORCID: https://orcid.org/0000-0003-3703-1268)
- Elżbieta Patkowska (ORCID: https://orcid.org/0000-0001-8691-4310)
- Kamil Brzozowski
- Krzysztof Gawroński (ORCID: https://orcid.org/0000-0002-9404-6020)
- Małgorzata Raźny (ORCID: https://orcid.org/0000-0001-8503-6114)
- Tomasz Gromek
- Andrzej B Szczepanik (ORCID: https://orcid.org/0000-0001-8322-0815)
Institutions
- Poznan University of Medical Sciences (PL)
- Medical University of Lublin (PL)
- Medical University of Silesia (PL)
- Medical University of Warsaw (PL)
- Nicolaus Copernicus University (PL)
- Instytut Hematologii i Transfuzjologi (PL)
- Copernicus Memorial Hospital (PL)
- Holy Cross University (PL)
- Medical University of Lodz (PL)
- National Institute Of Blood Disease and Bone Marrow Transplantation (PK)
- University of Warmia and Mazury in Olsztyn (PL)
Publication Details
- Journal
- Acta Haematologica Polonica
- Published
- 2024-09-30
- DOI
- https://doi.org/10.5603/ahp.101972
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Łódzki